%0 Journal Article
%T SGLT-2 inhibitors in chronic peritoneal dialysis patients: a follow-up study.
%A Lai JW
%A Wang CCN
%A Chou CY
%J BMC Nephrol
%V 25
%N 1
%D 2024 Jul 29
%M 39075357
%F 2.585
%R 10.1186/s12882-024-03683-y
%X <B>BACKGROUND: </B>Sodium-glucose transporter-2 inhibitors (SGLT-2i) are recommended for use in patients with type 2 diabetes comorbid atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease. Limited reports are currently available for their use in dialysis patients. In an observational, retrospective follow-up study, we reported the clinical characteristics of chronic peritoneal dialysis (PD) patients on SGLT-2i.<BR><B>METHODS: </B>We enrolled 50 diabetic chronic PD patients, and 11 continued SGLT-2i after PD treatment. We reported the patients' ultrafiltration, HbA1c, urinary tract infection episodes, and venous CO2 during follow-up and compared the differences in these factors between patients with and without SGLT-2i.<BR><B>RESULTS: </B>The mean age of the patients was 65 ± 15 years, and 16 (32%) patients were female. The age, gender, heart failure, and primary kidney disease were not different between patients with and without SGLT-2i at enrollment. In an average of 31 months follow-up, patients with SGLT-2i had higher ultrafiltration (1322 ± 200 ml/day vs. 985 ± 415 ml/day, p = 0.013), hemoglobin (11.2 ± 1.7 vs. 10.2 ± 1.7 g/dl), white blood cell count (9.2 ± 3.7 vs. 7.4 ± 2.1 109/L), and a lower venous CO2 (p = 0.036). The urine amount, the overall survival, the technical survival, and the chance of UTI were not different between patients with and without SGLT2i.<BR><B>CONCLUSIONS: </B>SGLT-2i may increase ultrafiltration volume and hemoglobin levels in chronic PD patients. SGLT-2i did not increase urinary tract infection but was linked to subclinical metabolic acidosis.<BR><B>UNASSIGNED: </B>The effect of SGLT-2i in chronic PD patients is not clear?<BR><B>UNASSIGNED: </B>SGLT-2i is associated with increased ultrafiltration, hemoglobin, white blood cell counts, and a decreased CO2 in PD patient.<BR><B>UNASSIGNED: </B>SGLT-2i may increase ultrafiltration in PD patients.