%0 Journal Article
%T Refinement of Risk-Stratification of Cytogenetically Normal Acute Myeloid Leukemia Adult Patients by MN1 Expression.
%A Ningombam A
%A Verma D
%A Kumar R
%A Singh J
%A Ali MS
%A Pandey AK
%A Singh I
%A Bakhshi S
%A Sharma A
%A Pushpam D
%A Palanichamy JK
%A Tanwar P
%A Ranjan Singh A
%A Chopra A
%J Asian Pac J Cancer Prev
%V 25
%N 7
%D 2024 Jul 1
%M 39068559
暂无%R 10.31557/APJCP.2024.25.7.2283
%X <B>BACKGROUND: </B>Acute myeloid leukemia with normal cytogenetics (CN-AML) represents a heterogeneous group having diverse genetic mutations. Understanding the significance of each of these mutations is necessary. In this study, we evaluated the prognostic role of MN1 expression in adult CN-AML patients.<BR><B>METHODS: </B>One hundred and sixty-three de-novo adult AML patients were evaluated for MN1 expression by real-time PCR. MN1 expression was correlated with the clinical characteristics of the patients and their outcomes.<BR><B>RESULTS: </B>Higher MN1 expression was associated with NPM1 wild-type (p<0.0001), CD34 positivity (p=0.006), and lower clinical remission rate (p=0.027). FLT3-ITD and CEBPA mutations had no association with MN1 expression. On survival analysis, a high MN1 expression was associated with poor event-free survival (Hazard Ratio 2.47, 95% Confidence Interval: 1.42-4.3; p<0.0001) and overall survival (Hazard Ratio 4.18, 95% Confidence Interval: 2.17-8.08; p<0.0001). On multivariate analysis, the MN1 copy number emerged as an independent predictor of EFS (p<0.0001) and OS (p<0.0001).<BR><B>CONCLUSIONS: </B>MN1 expression is an independent predictor of outcome in CN-AML.