%0 Journal Article %T Hyperoxic recovery interferes with the metabolic imprint of hypoxic exercise. %A Burtscher J %A Paglia G %A Denti V %A Faulhaber M %A Weiss G %A Schobersberger W %A Dünnwald T %J Free Radic Biol Med %V 223 %N 0 %D 2024 Jul 26 %M 39067627 %F 8.101 %R 10.1016/j.freeradbiomed.2024.07.024 %X Supplemental oxygen (hyperoxia) improves physical performance during hypoxic exercise. Based on the analysis of metabolome and iron homeostasis from human athlete blood samples, we show that hyperoxia during recovery periods interferes with metabolic alterations following hypoxic exercise. This may impair beneficial adaptations to exercise and/or hypoxia and highlights risks of oxygen supplementation in hypoxia.