%0 Journal Article
%T The Evolution of Genetic Variability at the LRRK2 Locus.
%A Guenther DT
%A Follett J
%A Amouri R
%A Sassi SB
%A Hentati F
%A Farrer MJ
%J Genes (Basel)
%V 15
%N 7
%D 2024 Jul 3
%M 39062657
%F 4.141
%R 10.3390/genes15070878
%X Leucine-rich repeat kinase 2 (LRRK2) c.6055G>A (p.G2019S) is a frequent cause of Parkinson's disease (PD), accounting for >30% of Tunisian Arab-Berber patients. LRRK2 is widely expressed in the immune system and its kinase activity confers a survival advantage against infection in animal models. Here, we assess haplotype variability in cis and in trans of the LRRK2 c.6055G>A mutation, define the age of the pathogenic allele, explore its relationship to the age of disease onset (AOO), and provide evidence for its positive selection.