%0 Journal Article
%T Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
%A Tehrani ZR
%A Habibzadeh P
%A Flinko R
%A Chen H
%A Abbasi A
%A Yared JA
%A Ciupe SM
%A Lewis GK
%A Sajadi MM
%J J Infect Dis
%V 230
%N 1
%D 2024 Jul 25
%M 39052732
%F 7.759
%R 10.1093/infdis/jiad603
%X Generation of a stable long-lived plasma cell (LLPC) population is the sine qua non of durable antibody responses after vaccination or infection. We studied 20 individuals with a prior coronavirus disease 2019 infection and characterized the antibody response using bone marrow aspiration and plasma samples. We noted deficient generation of spike-specific LLPCs in the bone marrow after severe acute respiratory syndrome coronavirus 2 infection. Furthermore, while the regression model explained 98% of the observed variance in anti-tetanus immunoglobulin G levels based on LLPC enzyme-linked immunospot assay, we were unable to fit the same model with anti-spike antibodies, again pointing to the lack of LLPC contribution to circulating anti-spike antibodies.