%0 Journal Article
%T Optimization of handheld spectrally encoded coherence tomography and reflectometry for point-of-care ophthalmic diagnostic imaging.
%A Watson JJ
%A Hecht R
%A Tao YK
%J J Biomed Opt
%V 29
%N 7
%D 2024 Jul
%M 39050778
%F 3.758
%R 10.1117/1.JBO.29.7.076006
%X <B>UNASSIGNED: </B>Handheld optical coherence tomography (HH-OCT) systems enable point-of-care ophthalmic imaging in bedridden, uncooperative, and pediatric patients. Handheld spectrally encoded coherence tomography and reflectometry (HH-SECTR) combines OCT and spectrally encoded reflectometry (SER) to address critical clinical challenges in HH-OCT imaging with real-time en face retinal aiming for OCT volume alignment and volumetric correction of motion artifacts that occur during HH-OCT imaging.<BR><B>UNASSIGNED: </B>We aim to enable robust clinical translation of HH-SECTR and improve clinical ergonomics during point-of-care OCT imaging for ophthalmic diagnostics.<BR><B>UNASSIGNED: </B>HH-SECTR is redesigned with (1) optimized SER optical imaging for en face retinal aiming and retinal tracking for motion correction, (2) a modular aluminum form factor for sustained alignment and probe stability for longitudinal clinical studies, and (3) one-handed photographer-ergonomic motorized focus adjustment.<BR><B>UNASSIGNED: </B>We demonstrate an HH-SECTR imaging probe with micron-scale optical-optomechanical stability and use it for in vivo human retinal imaging and volumetric motion correction.<BR><B>UNASSIGNED: </B>This research will benefit the clinical translation of HH-SECTR for point-of-care ophthalmic diagnostics.