%0 Journal Article
%T Baseline lung allograft dysfunction after bilateral deceased-donor lung transplantation: A single-center experience in Japan.
%A Yamaguchi M
%A Kawashima M
%A Muraoka T
%A Yamaya T
%A Cong Y
%A Nakao K
%A Nagano M
%A Konoeda C
%A Kage H
%A Sato M
%J Respir Investig
%V 62
%N 5
%D 2024 Sep 23
%M 39047315
暂无%R 10.1016/j.resinv.2024.07.009
%X <B>BACKGROUND: </B>Baseline lung allograft dysfunction (BLAD) refers to a condition in which a lung transplant recipient does not achieve normal pulmonary function (i.e., forced expiratory volume in 1 s or forced vital capacity of <80% of predicted values). Although BLAD is reportedly associated with a poor prognosis, the condition has not been examined in Japanese patients.<BR><B>METHODS: </B>In this study, we retrospectively examined 38 Japanese adults who underwent bilateral lung transplantation from 2015 to 2022 in a single center.<BR><B>RESULTS: </B>Twenty-one (55%) patients met the criteria for BLAD. No significant differences were found in recipient or donor factors between the BLAD and non-BLAD groups, but the donor-recipient ratio of the predicted vital capacity was lower in the BLAD group (p = 0.009). The intensive care unit length of stay, ventilator duration, and blood loss during transplant surgery were significantly higher in the BLAD group (p < 0.05). No significant difference was found in survival. The median observation period was significantly shorter in the BLAD than non-BLAD group (744 vs.1192 days, respectively; p = 0.031). The time to reach the normal threshold of pulmonary function after lung transplantation varied among the patients, ranging from 6 months to 4 years.<BR><B>CONCLUSIONS: </B>The characteristics of these Japanese patients with BLAD were similar to those of other patients in previous reports. The effects of the observation period and donor-recipient age discrepancy on BLAD require further exploration.