%0 Case Reports
%T Challenges in the treatment of BRAF K601E-mutated lung carcinoma: a case report of rapid response and resistance to dabrafenib and trametinib.
%A Nishiyama A
%A Sato S
%A Sakaguchi H
%A Kotani H
%A Yamashita K
%A Ohtsubo K
%A Nanjo S
%A Yano S
%A Mizuguchi K
%A Ikeda H
%A Takeuchi S
%J Front Oncol
%V 14
%N 0
%D 2024
%M 39040442
%F 5.738
%R 10.3389/fonc.2024.1374594
%X We report a case of limited effectiveness of dabrafenib and trametinib in a 59-year-old man with poorly differentiated lung carcinoma and a rare BRAF K601E mutation. The patient, unresponsive to chemotherapy and immunotherapy, received these targeted agents as second-line treatment. Despite a notable initial response, tumor regression lasted only 52 days. A subsequent liquid biopsy revealed additional alterations (BRAF amplification, KIT amplification, TP53 S241F), indicating a complex resistance mechanism. This case underscores the challenges in treating BRAF K601E-mutant lung carcinoma, emphasizing the need for advanced molecular diagnostics, personalized approaches, and further research into more effective therapies for unique genetic profiles.