%0 Journal Article
%T Association between the IL1B-511 C>T polymorphism and the risk of hematologic malignancies: data from a meta-analysis.
%A Alves-Hanna FS
%A Silva FRP
%A Pereira DS
%A Leal ALAB
%A Magalhães-Gama F
%A Costa AG
%J Cancer Biol Ther
%V 25
%N 1
%D 2024 Dec 31
%M 39039694
%F 4.875
%R 10.1080/15384047.2024.2382503
%X The relationship between the IL1B-511C>T (rs16944) polymorphism and the risk of developing hematologic malignancies remains controversial. Thus, we performed a meta-analysis to evaluate the association between IL1B-511C>T polymorphism and the risk of developing hematologic malignancies. A comprehensive search was conducted to identify all eligible studies on IL1B-511C>T polymorphism and hematologic malignancies. Twelve case-control studies, with 2,896 cases and 3,716 controls, were selected for the analysis. The overall data failed to indicate a significant association between IL1B-511C>T polymorphism and the risk of hematologic malignancies (OR:1.06, 95% Confidence Interval [CI]: 0.93-1.22). Moreover, non-significant associations were observed in a stratified analysis according to neoplasm type (multiple myeloma, Hodgkin's lymphoma, and non-Hodgkin's lymphoma), ethnicity (European and Asian), and Hardy-Weinberg equilibrium. In summary, our results suggest that there is no association between the IL1B-511C>T polymorphism and the risk of hematologic malignancies. As such, further large-scale studies are needed to confirm our findings.