%0 Case Reports %T An Unusual Case of Paroxysmal Third-Degree Atrioventricular Block: Thinking Outside the Box. %A Sabella-Jiménez V %A Duran Luciano P %A Otero-Herrera C %A Espiche C %A Triana AJ %A Celaj S %J Cureus %V 16 %N 6 %D 2024 Jun %M 39036118 暂无%R 10.7759/cureus.62782 %X During the assessment of a third-degree atrioventricular (AV) block in a patient with syncope, different etiologies should be considered and evaluated. Extrinsic vagal paroxysmal AV block, extrinsic idiopathic AV block and intrinsic paroxysmal AV block are among the types of third-degree AV block in the differential diagnoses. Extrinsic vagal paroxysmal third-degree atrioventricular block (EV-AVB) is linked to parasympathetic influence on cardiac conduction and can be observed in bladder distention and urinary retention. Topical and ophthalmic beta-blockers have shown systemic effects such as bradycardia with and without syncope. We present the case of an 80-year-old male with symptomatic EV-AVB likely precipitated by bladder outlet obstruction and chronic use of an ophthalmic beta-blocker, often overlooked causes of third-degree AV block.