%0 Journal Article
%T Long-term clinical outcomes of male breast cancer patients treated with curative intent by trimodality therapy at an academic university hospital in India.
%A Chakrabarti D
%A Ghosh A
%A Qayoom S
%A Manjunath S
%A Khalid B
%A Rajan S
%A Akhtar N
%A Ramakant P
%A Verma M
%A Srivastava K
%A Kumar V
%A Gupta R
%A Mishra AK
%A Bhatt MLB
%J J Med Imaging Radiat Oncol
%V 0
%N 0
%D 2024 Jul 21
%M 39034491
%F 1.667
%R 10.1111/1754-9485.13733
%X <B>BACKGROUND: </B>Male breast cancer is rare and accounts for less than 1% of all breast cancer cases worldwide.<BR><B>METHODS: </B>This retrospective cohort study included all patients of invasive male breast cancer treated with curative intent by a trimodality approach via a multidisciplinary team at an academic university hospital in India between 2009 and 2023. Records were identified from a prospectively maintained database. Clinicopathological parameters, treatment details and survival were recorded and analysed.<BR><B>RESULTS: </B>Thirty-four patients were included. The median (IQR) age was 55(44-63) years. Most patients were overall stage III (74%) and node positive (79%) with Scarff-Bloom-Richardson grade II (50%). Twenty-five patients (73%) were oestrogen receptor (ER) positive. Lymphovascular space invasion (LVSI) and perineural invasion (PNI) were present in 62% and 21% of patients, respectively. The most common chemotherapy timing was adjuvant (53%) followed by neoadjuvant (41%), and the most commonly used regimen consisted of a combination of doxorubicin-cyclophosphamide followed by a taxane (53%). Most (85%) patients underwent a mastectomy, five patients underwent breast conservation. All patients received radiotherapy to a dose of 42.6 Gy in 16 fractions, followed by a tumour bed boost for those undergoing breast conservation. At a median follow-up of 70 months (range 10-159 months), the five and ten-year overall survival was 91% and 58%, and the five-year disease-free survival (DFS) was 67%. The median DFS was 72 months. On univariate analysis, the tumour sub-type (Luminal versus TNBC) significantly predicted DFS (P = 0.03 log-rank).<BR><B>CONCLUSIONS: </B>Breast cancer in males has a high incidence of node positivity, ER positivity and LVSI. Even with advanced stages at presentation, trimodality therapy in a multidisciplinary setting offers good long-term outcomes.