%0 Journal Article
%T The Effect of Age and Other Patient Characteristics on Outcomes Among Nontransplanted Patients Who Were Treated With First-Line Lenalidomide, Bortezomib, and Dexamethasone: Results From the ConnectⓇ MM Registry.
%A Abonour R
%A Lee HC
%A Rifkin R
%A Ailawadhi S
%A Omel J
%A Hardin JW
%A Narang M
%A Toomey K
%A Gasparetto C
%A Wagner LI
%A Terebelo H
%A Mouro J
%A Dhanasiri S
%A Liu L
%A Yu E
%A Jagannath S
%J Clin Lymphoma Myeloma Leuk
%V 0
%N 0
%D 2024 Jun 3
%M 39033038
%F 2.822
%R 10.1016/j.clml.2024.05.021
%X <B>BACKGROUND: </B>Lenalidomide (R), bortezomib (V), and dexamethasone (d) is a standard-of-care regimen in newly diagnosed multiple myeloma (NDMM); however, characteristics and outcomes for nontransplanted patients receiving frontline RVd are not well understood.<BR><B>METHODS: </B>The ConnectⓇ MM Registry is a large, US, multicenter, prospective observational cohort study of NDMM patients.<BR><B>METHODS: </B>This analysis investigated characteristics and outcomes of patients who received RVd alone or followed by Rd or R (RVd ± Rd/R) who did not undergo frontline autologous stem cell transplantation.<BR><B>RESULTS: </B>As of August 2021, 314 of 1979 nontransplanted patients received RVd ± Rd/R as initial therapy. Of these, 135 were aged ≤ 65 years and 179 were > 65 years. 108 patients had time to relapse (TTR) of ≤ 12 months and 182 had TTR > 12 months. Baseline characteristics were comparable regardless of TTR and age group except renal function, which was more commonly impaired in older patients. Among patients aged ≤ 65 and > 65 years, median duration of first-line treatment was 6.3 and 9.0 months, median time to next line for those who received second-line therapy was 15.5 and 15.2 months, median progression-free survival (PFS) was 19.3 and 23.0 months, and median overall survival was 60.0 and 59.1 months, respectively. High-risk disease (per IMWG criteria) and high serum calcium were associated with higher hazard of progression or death; the adjusted PFS hazard ratio with respect to age (≤ 65 vs. > 65 years) based on multivariable analysis was 1.18 (0.89-1.57; P = .25).<BR><B>CONCLUSIONS: </B>These results indicate RVd is active across age groups and provide a better understanding of outcomes with RVd in NDMM.