%0 Journal Article
%T Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex.
%A Varlı M
%A Kim E
%A Oh S
%A Pulat S
%A Zhou R
%A Gamage CDB
%A Gökalsın B
%A Sesal NC
%A Kim KK
%A Paik MJ
%A Kim H
%J Cancer Cell Int
%V 24
%N 1
%D 2024 Jul 20
%M 39030594
%F 6.429
%R 10.1186/s12935-024-03434-x
%X <B>BACKGROUND: </B>Expression of the KITENIN/ErbB4 oncogenic complex is associated with metastasis of colorectal cancer to distant organs and lymph nodes and is linked with poor prognosis and poor survival.<BR><B>METHODS: </B>Here, we used in vitro and in silico methods to test the ability of chrysophanol, a molecule of natural origin, to suppress the progression of colorectal cancer by targeting the KITENIN/ErbB4 complex.<BR><B>RESULTS: </B>Chrysophanol binds to ErbB4, disrupting the ErbB4/KITENIN complex and causing autophagic degradation of KITENIN. We demonstrated that chrysophanol binds to ErbB4 according to a molecular docking model. Chrysophanol reversed KITENIN-mediated effects on cell motility, aerobic glycolysis, and expression of downstream effector genes. Moreover, under conditions of KITENIN overexpression, chrysophanol suppressed the production of onco-metabolites.<BR><B>CONCLUSIONS: </B>Chrysophanol suppresses oncogenic activities by targeting the KITENIN/ErbB4 complex.