%0 Journal Article
%T Highly selective Zn2+ near-infrared fluorescent probe and its application in biological imaging.
%A Song Q
%A Bai C
%A Dong Y
%A Chen M
%A Wang S
%A Hu J
%A Qiao X
%A Chen J
%A Li S
%A Liu X
%A Wang X
%A Qiao R
%A Qu C
%A Miao H
%J Spectrochim Acta A Mol Biomol Spectrosc
%V 322
%N 0
%D 2024 Dec 5
%M 39029204
%F 4.831
%R 10.1016/j.saa.2024.124828
%X Zn2+ plays a vital role in regulating various life processes, such as gene expression, cell signaling, and brain function. In this study, a near-infrared fluorescent probe AXS was synthesized to detect Zn2+ with good fluorescence specificity, high selectivity, and high sensitivity; the detection limit of Zn2+ was 6.924 × 10-11 M. The mechanism of Zn2+ recognition by the AXS probe was investigated by 1H nuclear magnetic resonance titrations, UV-visible spectroscopy, fluorescence spectroscopy, Fourier-transform infrared spectroscopy, and high-resolution mass spectrometry. Test paper experiments showed that the AXS probe could detect Zn2+ in real samples. In addition, quantitative and qualitative detection of Zn2+ in common foodstuffs was achieved. For portable Zn2+ detection, a smartphone detection platform was also developed based on the AXS probe. Importantly, the AXS probe showed good bioimaging capabilities in Caenorhabditis elegans and mice.