%0 Journal Article
%T Fatty infiltration and ventricular premature beats originating from right ventricular outflow tract: association or causality?
%A Sîrbu Prisecaru RV
%A Riahi L
%A Abagiu M
%A Purcar OE
%A Vlădoianu MCC
%A Leaţu CG
%A Sîrbu AD
%A Maniţiu I
%J Rom J Morphol Embryol
%V 65
%N 2
%D 2024 Apr-Jun
%M 39020544
%F 0.833
%R 10.47162/RJME.65.2.16
%X <B>BACKGROUND: </B>Anatomical evidence reveals heterogeneous fat distribution in both atrial and ventricular myocardium that are considered normal, but at the same time arrhythmogenic, and numerous cardiac pathophysiological conditions are associated with myocardial fat deposits. The relationship between fatty infiltration, especially in the epicardial layer and its pathophysiological implication is not completely understood.<BR><B>OBJECTIVE: </B>The aim of this study was to establish a positive or negative relationship between the ventricular burden and several parameters related to right ventricle (RV) adipose tissue - the RV thickness, RV indexed mass, body mass index (BMI), age, gender.<BR><B>METHODS: </B>Twenty-three patients with documented premature ventricular contractions (PVCs) originating from right ventricular outflow tract based on electrocardiography (ECG) evaluation were hospitalized between January 2018-November 2022 for electrophysiological study and PVCs ablation. Data obtained after collecting the clinical characteristics, ECG, RV measurements from transthoracic echocardiography (TTE), cardiac computed tomography (CT) and magnetic resonance imaging (MRI) were analyzed.<BR><B>RESULTS: </B>A weak positive relationship between the ventricular burden and BMI (r=0.14, p=0.49), tricuspid annular plane systolic excursion (TAPSE) (r=0.07, p=0.7), the RV thickness (r=0.03, p=0.8), epicardial adipose tissue (r=0.13, p=0.55), RV mass indexed (r=0.05, p=0.82) was observed. No clear cut-off of the PVCs burden could be established in terms related to the increase in BMI, RV thickness, epicardial adipose tissue, RV mass indexed.<BR><B>CONCLUSIONS: </B>No significant positive or negative relationship between the ventricular burden and the RV thickness, RV indexed mass were found in individuals with a high PVCs originating from right ventricular outflow tract (RVOT) burden.