%0 Journal Article
%T Synthesis and biological evaluation of vioprolide B and its dehydrobutyrine-glycine analogue.
%A Osorio Reineke N
%A Elsen FAV
%A Grab HA
%A Mostert D
%A Sieber SA
%A Bach T
%J Chem Commun (Camb)
%V 60
%N 63
%D 2024 Aug 1
%M 39015034
%F 6.065
%R 10.1039/d4cc02946a
%X Herein, we describe the total synthesis of the depsipeptide vioprolide B and of an analogue, in which the (E)-dehydrobutyrine amino acid was replaced by glycine. The compounds were studied in biological assays which revealed cytotoxicity solely for vioprolide B presumably by covalent binding to cysteine residues of elongation factor eEF1A1 and of chromatin assembly factor CHAF1A.