%0 Journal Article %T Well-modulated interfacial ion transport enables D-sorbitol/PEDOT:PSS fibers to sense brain electrophysiological signals in vivo. %A Xu T %J Chem Commun (Camb) %V 60 %N 63 %D 2024 Aug 1 %M 39011590 %F 6.065 %R 10.1039/d4cc01867b %X A neuroelectrode can be easily prepared using a wet-spun fiber of D-sorbitol/PEDOT:PSS. At a D-sorbitol/PEDOT:PSS weight ratio of 6, the fiber is well-modulated with suitable characters, including the morphology, crystallization, diffusion resistance (179 kΩ), and electric double-layer capacitance (2.72 μF), for sensitive recording of brain activity during somatosensory stimulation and seizures. Additionally, the fiber is highly biocompatible with the brain. This study presents a simple and controllable strategy for the chemical construction of conducting polymer-based neurosensors.