%0 Journal Article
%T Genetic variants of ABCB1 and CES1 genes on dabigatran metabolism in the Kazakh population.
%A Abdrakhmanov A
%A Zholdybayeva E
%A Shaimerdinova A
%A Kulmambetova G
%A Abildinova S
%A Albayev R
%A Tuyakova G
%A Rib E
%A Suleimen Z
%A Abdrakhmanova Z
%A Bekbossynova M
%J Caspian J Intern Med
%V 15
%N 3
%D 2024
%M 39011438
暂无%R 10.22088/cjim.15.3.499
%X <B>UNASSIGNED: </B>Allelic variants of genes encoding enzymes of the esterase system (CES1) and P-glycoprotein (ABCB1) can change the metabolism and pharmacokinetics of dabigatran. Therefore, they act as determining factors in the development of side effects, especially bleeding. We analyzed the genotype-phenotype relationship of ABCB1 (rs1045642, rs4148738, rs2032582, and rs1128503) and CES1 (rs8192935, rs71647871, and rs2244613) polymorphisms in patients with atrial fibrillation who had been treated with dabigatran.<BR><B>UNASSIGNED: </B>A total of 150 patients were recruited for this study. TaqMan technology was used for SNP genotyping.<BR><B>UNASSIGNED: </B>Patients with the rs2244613 GG genotype had a lower concentration (55.27 ± 34.22 ng/ml) compared to those with the TT genotype (63.33 ± 52.25 ng/ml) (additive model, P = 0.000). Individuals with the rs8192935 AA genotype had a lower concentration (52.72 ± 30.45 ng/ml) compared to those with the GG genotype (79.78 ± 57 ng/ml) (additive model, P = 0.001). The APTT values among the different genotypes of the ABCB1 SNPs, rs4148738 and rs1045642, were significantly different (P = 0.035 and P = 0.024, respectively).<BR><B>UNASSIGNED: </B>Our research demonstrates that the CES1 polymorphisms, rs8192935 and rs2244613, are associated with the pharmacodynamics and pharmacokinetics of dabigatran in the Kazakh subpopulation.