%0 Journal Article
%T Energy-transfer Enabled Divergent Synthesis of Polycyclic γ-Sultines.
%A Zhou P
%A Zhang Y
%A Ma X
%A Yang X
%A Fang X
%A Lu X
%A Shu C
%J Chemistry
%V 0
%N 0
%D 2024 Jul 14
%M 39003675
%F 5.02
%R 10.1002/chem.202401369
%X A visible-light-initiated energy-transfer enabled radical cyclization for the divergent synthesis of polycyclic γ-sultine derivatives has been developed. The reaction provides an alternative and expeditious access to benzofused γ-sultine frameworks, the analogues of γ-lactones and γ-sultones, and features good functional group compatibility, mild reaction conditions and excellent diastereoselectivity. The robustness and application potential of this method have also been successfully displayed by two gram-scale reactions and the synthesis of polycyclic sultones. Mechanistic studies indicated the transformations through a possible energy-transfer enabled intramolecular radical homolytic substitution or hydrogen atom transfer process mainly.