%0 Journal Article
%T Elucidating the catalytic mechanism of Prussian blue nanozymes with self-increasing catalytic activity.
%A Feng K
%A Wang Z
%A Wang S
%A Wang G
%A Dong H
%A He H
%A Wu H
%A Ma M
%A Gao X
%A Zhang Y
%J Nat Commun
%V 15
%N 1
%D 2024 Jul 13
%M 39003316
%F 17.694
%R 10.1038/s41467-024-50344-7
%X Although Prussian blue nanozymes (PBNZ) are widely applied in various fields, their catalytic mechanisms remain elusive. Here, we investigate the long-term catalytic performance of PBNZ as peroxidase (POD) and catalase (CAT) mimetics to elucidate their lifespan and underlying mechanisms. Unlike our previously reported Fe3O4 nanozymes, which exhibit depletable POD-like activity, the POD and CAT-like activities of PBNZ not only persist but slightly enhance over prolonged catalysis. We demonstrate that the irreversible oxidation of PBNZ significantly promotes catalysis, leading to self-increasing catalytic activities. The catalytic process of the pre-oxidized PBNZ can be initiated through either the conduction band pathway or the valence band pathway. In summary, we reveal that PBNZ follows a dual-path electron transfer mechanism during the POD and CAT-like catalysis, offering the advantage of a long service life.