%0 Journal Article
%T Role of V-Y flap reconstruction in vulvar cancer patients: multicenter retrospective study.
%A Di Donato V
%A Giannini A
%A Galli V
%A Di Donna MC
%A Congiu MA
%A Garganese G
%A Plotti F
%A Sorbi F
%A Golia D'Augè T
%A Laganà AS
%A Gentileschi S
%A Caretto AA
%A Cuccu I
%A Falcone F
%A Malzoni M
%A Ricciardi E
%A Perniola G
%A Turetta C
%A Plett H
%A Fambrini M
%A Chiantera V
%A Vizza E
%A Angioli R
%A Raspagliesi F
%A Muzii L
%A Scambia G
%A Benedetti Panici P
%A Bogani G
%J Int J Gynecol Cancer
%V 34
%N 8
%D 2024 Aug 5
%M 39002981
%F 4.661
%R 10.1136/ijgc-2024-005486
%X <B>OBJECTIVE: </B>To assess if the use of a V-Y reconstructive flap after excisional radical surgery positively influences the surgical outcomes in patients with vulvar cancer.<BR><B>METHODS: </B>This was a multicenter, retrospective, controlled study. Surgical outcomes and complication rates of women with invasive vulvar cancer who underwent radical surgery and vulvar reconstruction and those who underwent radical surgery without the reconstruction step were compared. Only patients who underwent bilateral or unilateral V-Y advancement fascio-cutaneous flaps were included in the reconstruction group. Univariate and multivariate logistic regression models were used to analyze predicting variables for their association with complication rates.<BR><B>RESULTS: </B>Overall, 361 patients were included: 190 (52%) underwent the reconstructive step after the excisional radical procedure and were compared with 171 (47.4%) who did not undergo the reconstructive step. At multivariate analysis, body mass index >30 kg/m2 (odds ratio (OR) 3.36, p=0.007) and diabetes (OR 2.62, p<0.022) were independently correlated with wound infection. Moreover, increasing age (OR 1.52, p=0.009), body mass index >30 kg/m2 (OR 3.21, p=0.002,) and International Federation of Gynecology and Obstetrics (FIGO) stages III-IV (OR 2.25, p=0.017) were independent predictors of wound dehiscence. A significant reduction in the incidence of postoperative wound complications among patients who underwent V-Y reconstructive flaps was demonstrated. This was correlated more significantly in women with lesions >4 cm.<BR><B>CONCLUSIONS: </B>The adoption of V-Y flaps in vulvar surgery was correlated with reduced surgical related complications, particularly in vulnerable patients involving large surgical defects following excisional radical procedures.