%0 Journal Article
%T NMDAR dysfunction and the regulation of dopaminergic transmission in schizophrenia.
%A Dwyer GE
%A Johnsen E
%A Hugdahl K
%J Schizophr Res
%V 271
%N 0
%D 2024 Jul 12
%M 39002526
%F 4.662
%R 10.1016/j.schres.2024.07.025
%X A substantial body of evidence implicates dysfunction in N-methyl-d-aspartate receptors (NMDARs) in the pathophysiology of schizophrenia. This article illustrates how NMDAR dysfunction may give rise to many of the neurobiological phenomena frequently associated with schizophrenia with a particular focus on how NMDAR dysfunction affects the thalamic reticular nucleus (nRT) and pedunculopontine tegmental nucleus (PPTg). Furthermore, this article presents a model for schizophrenia illustrating how dysfunction in the nRT may interrupt prefrontal regulation of midbrain dopaminergic neurons, and how dysfunction in the PPTg may drive increased, irregular burst firing.