%0 Journal Article
%T Pills of Multi-Target H2S Donating Molecules for Complex Diseases.
%A Corvino A
%A Scognamiglio A
%A Fiorino F
%A Perissutti E
%A Santagada V
%A Caliendo G
%A Severino B
%J Int J Mol Sci
%V 25
%N 13
%D 2024 Jun 27
%M 39000122
%F 6.208
%R 10.3390/ijms25137014
%X Among the various drug discovery methods, a very promising modern approach consists in designing multi-target-directed ligands (MTDLs) able to modulate multiple targets of interest, including the pathways where hydrogen sulfide (H2S) is involved. By incorporating an H2S donor moiety into a native drug, researchers have been able to simultaneously target multiple therapeutic pathways, resulting in improved treatment outcomes. This review gives the reader some pills of successful multi-target H2S-donating molecules as worthwhile tools to combat the multifactorial nature of complex disorders, such as inflammatory-based diseases and cancer, as well as cardiovascular, metabolic, and neurodegenerative disorders.