%0 Journal Article %T The Phosphorus-Iron Nexus: Decoding the Nutrients Interaction in Soil and Plant. %A Yang X %A Liu C %A Liang C %A Wang T %A Tian J %J Int J Mol Sci %V 25 %N 13 %D 2024 Jun 26 %M 39000100 %F 6.208 %R 10.3390/ijms25136992 %X Phosphorus (P) and iron (Fe) are two essential mineral nutrients in plant growth. It is widely observed that interactions of P and Fe could influence their availability in soils and affect their homeostasis in plants, which has received significant attention in recent years. This review presents a summary of latest advances in the activation of insoluble Fe-P complexes by soil properties, microorganisms, and plants. Furthermore, we elucidate the physiological and molecular mechanisms underlying how plants adapt to Fe-P interactions. This review also discusses the current limitations and presents potential avenues for promoting sustainable agriculture through the optimization of P and Fe utilization efficiency in crops.