%0 Journal Article
%T The Role of the JAK-STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia.
%A Ziętara KJ
%A Wróblewska K
%A Zajączkowska M
%A Taczała J
%A Lejman M
%J Int J Mol Sci
%V 25
%N 13
%D 2024 Jun 21
%M 38999955
%F 6.208
%R 10.3390/ijms25136844
%X B-cell lymphoblastic leukemia is a hematologic neoplasm that poses a serious health concern in childhood. Genetic aberrations, such as mutations in the genes IL-7, IL7R, JAK1, JAK2, TLSP, CRLF2, and KTM2A or gene fusions involving BCR::ABL1, ETV6::RUNX1, and PAX5::JAK2, often correlate with the onset of this disease. These aberrations can lead to malfunction of the JAK-STAT signaling pathway, which is implicated in various important biological processes, including those related to immunology. Understanding the mechanisms underlying the malfunction of the JAK-STAT pathway holds potential for research on drugs targeting its components. Available drugs that interfere with the JAK-STAT pathway include fludarabine, ruxolitinib, and fedratinib.