%0 Journal Article
%T Connectome gradient dysfunction contributes to white matter hyperintensity-related cognitive decline.
%A Yang D
%A Tan Y
%A Zhou Z
%A Ke Z
%A Huang L
%A Mo Y
%A Tang L
%A Mao C
%A Hu Z
%A Cheng Y
%A Shao P
%A Zhang B
%A Zhu X
%A Xu Y
%J CNS Neurosci Ther
%V 30
%N 7
%D 2024 Jul
%M 38997814
%F 7.035
%R 10.1111/cns.14843
%X <B>BACKGROUND: </B>Although white matter hyperintensity (WMH) is closely associated with cognitive decline, the precise neurobiological mechanisms underlying this relationship are not fully elucidated. Connectome studies have identified a primary-to-transmodal gradient in functional brain networks that support the spectrum from sensation to cognition. However, whether connectome gradient structure is altered as WMH progresses and how this alteration is associated with WMH-related cognitive decline remain unknown.<BR><B>METHODS: </B>A total of 758 WMH individuals completed cognitive assessment and resting-state functional MRI (rs-fMRI). The functional connectome gradient was reconstructed based on rs-fMRI by using a gradient decomposition framework. Interrelations among the spatial distribution of WMH, functional gradient measures, and specific cognitive domains were explored.<BR><B>RESULTS: </B>As the WMH volume increased, the executive function (r = -0.135, p = 0.001) and information-processing speed (r = -0.224, p = 0.001) became poorer, the gradient range (r = -0.099, p = 0.006), and variance (r = -0.121, p < 0.001) of the primary-to-transmodal gradient reduced. A narrower gradient range (r = 0.131, p = 0.001) and a smaller gradient variance (r = 0.136, p = 0.001) corresponded to a poorer executive function. In particular, the relationship between the frontal/occipital WMH and executive function was partly mediated by gradient range/variance of the primary-to-transmodal gradient.<BR><B>CONCLUSIONS: </B>These findings indicated that WMH volume, the primary-to-transmodal gradient, and cognition were interrelated. The detrimental effect of the frontal/occipital WMH on executive function was partly mediated by the decreased differentiation of the connectivity pattern between the primary and transmodal areas.