%0 Journal Article
%T Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center.
%A Fernandez MV
%A Liu M
%A Beric A
%A Johnson M
%A Cetin A
%A Patel M
%A Budde J
%A Kohlfeld P
%A Bergmann K
%A Lowery J
%A Flynn A
%A Brock W
%A Sanchez Montejo B
%A Gentsch J
%A Sykora N
%A Norton J
%A Gentsch J
%A Valdez O
%A Gorijala P
%A Sanford J
%A Sun Y
%A Wang C
%A Western D
%A Timsina J
%A Mangetti Goncalves T
%A Do AN
%A Sung YJ
%A Zhao G
%A Morris JC
%A Moulder K
%A Holtzman DM
%A Bateman RJ
%A Karch C
%A Hassenstab J
%A Xiong C
%A Schindler SE
%A Balls-Berry JJ
%A Benzinger TLS
%A Perrin RJ
%A Denny A
%A Snider BJ
%A Stark SL
%A Ibanez L
%A Cruchaga C
%J Sci Data
%V 11
%N 1
%D 2024 Jul 12
%M 38997326
%F 8.501
%R 10.1038/s41597-024-03485-9
%X The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer Disease. Over more than 40 years, research volunteers have been recruited to participate in cognitive, neuropsychologic, imaging, fluid biomarkers, genomic and multi-omic studies. Tissue and longitudinal data collected to foster, facilitate, and support research on dementia and aging. The Genetics and high throughput -omics core (GHTO) have collected of more than 26,000 biological samples from 6,625 Knight-ADRC participants. Samples available include longitudinal DNA, RNA, non-fasted plasma, cerebrospinal fluid pellets, and peripheral blood mononuclear cells. The GHTO has performed deep molecular profiling (genomic, transcriptomic, epigenomic, proteomic, and metabolomic) from large number of brain (n = 2,117), CSF (n = 2,012) and blood/plasma (n = 8,265) samples with the goal of identifying novel risk and protective variants, identify novel molecular biomarkers and causal and druggable targets. Overall, the resources available at GHTO support the increase of our understanding of Alzheimer Disease.