%0 Journal Article
%T An atlas of causal association between micronutrients and osteoarthritis.
%A Wei W
%A Qi X
%A Cheng B
%A He D
%A Qin X
%A Zhang N
%A Zhao Y
%A Chu X
%A Shi S
%A Cai Q
%A Yang X
%A Cheng S
%A Meng P
%A Hui J
%A Pan C
%A Zhao B
%A Liu L
%A Wen Y
%A Liu H
%A Jia Y
%A Zhang F
%J Prev Med
%V 185
%N 0
%D 2024 Aug 10
%M 38997009
%F 4.637
%R 10.1016/j.ypmed.2024.108063
%X <B>OBJECTIVE: </B>This study examines the causal relationships between serum micronutrients and site-specific osteoarthritis (OA) using Mendelian Randomization (MR).<BR><B>METHODS: </B>This study performed a two-sample MR analysis to explore causal links between 21 micronutrients and 11 OA outcomes. These outcomes encompass overall OA, seven site-specific manifestations, and three joint replacement subtypes. Sensitivity analyses using MR methods, such as the weighted median, MR-Egger, and MR-PRESSO, assessed potential horizontal pleiotropy and heterogeneity. Genome-wide association summary statistical data were utilized for both exposure and outcome data, including up to 826,690 participants with 177,517 OA cases. All data was sourced from Genome-wide association studies datasets from 2009 to 2023.<BR><B>RESULTS: </B>In the analysis of associations between 21 micronutrients and 11 OA outcomes, 15 showed Bonferroni-corrected significance (P < 0.000216), without significant heterogeneity or horizontal pleiotropy. Key findings include strong links between gamma-tocopherol and spine OA (OR = 1.70), and folate with hand OA in finger joints (OR = 1.15). For joint replacements, calcium showed a notable association with a reduced likelihood of total knee replacement (TKR) (OR = 0.52) and total joint replacement (TJR) (OR = 0.56). Serum iron was significantly associated with an increased risk of total hip replacement (THR) (OR = 1.23), while folate indicated a protective effect (OR = 0.95). Various sex-specific associations were also uncovered.<BR><B>CONCLUSIONS: </B>These findings underscore the critical role of micronutrients in osteoarthritis, providing valuable insights for preventive care and potential enhancement of treatment outcomes.