%0 Journal Article %T Activity-induced reactivity of astrocytes impairs cognition. %A Bohmbach K %A Henneberger C %J PLoS Biol %V 22 %N 7 %D 2024 Jul %M 38996200 %F 9.593 %R 10.1371/journal.pbio.3002712 %X Glial cells such as astrocytes can modulate neuronal signaling. Astrocytes can also acquire a reactive phenotype that correlates with cognitive impairments in brain diseases. A study in PLOS Biology shows that prolonged activation of astrocytes can trigger both cognitive impairments and a reactive astrocyte phenotype.