%0 Case Reports
%T Ichthyosis uteri complicated by endometrial adenocarcinoma with transitional cell differentiation: A case report.
%A Ding L
%A Liu W
%A Li H
%A Huang D
%A Chen Y
%A An H
%J Medicine (Baltimore)
%V 103
%N 28
%D 2024 Jul 12
%M 38996162
%F 1.817
%R 10.1097/MD.0000000000038792
%X <B>BACKGROUND: </B>Ichthyosis uteri is a rare pathological condition characterized by the replacement of the endometrial lining by stratified squamous epithelium. Yet its occurrence with endometrial adenocarcinoma is very rare.<BR><B>METHODS: </B>A 68-year-old woman has been experiencing sporadic, minor vaginal hemorrhages for a few months. The gynecological evaluation revealed a uterine enlargement and imaging demonstrated an irregular mass within the uterus.<BR><B>METHODS: </B>Endometrial adenocarcinoma with transitional cell differentiation; ichthyosis uteri with dysplasia.<BR><B>METHODS: </B>Radical hysterectomy with pelvic lymphadenectomy was performed followed by postoperative radiotherapy.<BR><B>RESULTS: </B>Postoperative follow-up at 8 months showed a favorable outcome without signs of recurrence and metastasis.<BR><B>CONCLUSIONS: </B>Adequate pathological sampling is crucial to identifying the accompanying lesions of ichthyosis uteri. Finding molecular alterations in various pathological morphologies is important to understand the evolution of disease.