%0 Journal Article
%T The role of CD83 in the pathogenesis of immune thrombocytopenia.
%A Wang X
%A Zhou Q
%A Yang W
%A Bi H
%A Wang H
%A Wang Y
%A Du Y
%A Liu L
%A Liu Y
%A Yin L
%A Yao J
%A Yu J
%A Tao W
%A Zhou Y
%A Zhou Z
%J Hematology
%V 29
%N 1
%D 2024 Dec
%M 38994874
%F 2.264
%R 10.1080/16078454.2024.2372482
%X <B>UNASSIGNED: </B>CD83 are closely related to the pathogenesis of immune thrombocytopenia (ITP), but the exact mechanism remains unclear.<BR><B>UNASSIGNED: </B>To explore the relationship between CD83 and CD4+ T cell subsets and clarify the role of CD83 in the pathogenesis of ITP.<BR><B>UNASSIGNED: </B>RT-qPCR and Flow cytometry were used to illustrate CD83 expression. The downregulation and overexpression of DC-CD83 were co-cultured with CD4+ T cells to detect cell proliferation, co-cultured supernatant cytokines and Tregs expression.<BR><B>UNASSIGNED: </B>The results indicate that the ITP patients showed higher expression of CD83 than the healthy controls. The proliferation of CD4+ T cells was inhibited by downregulation of DCs-CD83 but promoted by overexpression of DCs-CD83. siRNA-CD83 inhibited proinflammatory IFN-γ and IL-17 secretion while raising TGF-β, IL-10 concentrations. Overexpression of DCs-CD83 promoted Tregs expression.<BR><B>UNASSIGNED: </B>The Th1/Th2 and Th17/Tregs polarization were reversed via interfering DCs with siRNA-CD83. CD83 plays an important role in ITP pathogenesis, suggesting novel treatment for ITP patients.