%0 Journal Article
%T Self-reporting intracellular delivery agent for singlet oxygen.
%A Li Y
%A Wang L
%A Zhang S
%A Liu Z
%A Sun R
%A Qiao Y
%A Akkaya EU
%J Chem Commun (Camb)
%V 60
%N 62
%D 2024 Jul 30
%M 38994648
%F 6.065
%R 10.1039/d4cc02209b
%X 1,4-Dimethylphenazine endoperoxide releases singlet oxygen with a half-life of 89 hours at 37 °C. The thermal cycloreversion reaction is accompanied by a strong increase in the emission intensity with a peak at 490 nm, due to the formation of the phenazine core. The endoperoxide is effective against cancer cells in culture medium and tumor spheroids, with singlet oxygen-mediated cytotoxicity.