%0 Journal Article %T Expanding the Application of Sentinel-2 Chlorophyll Monitoring across United States Lakes. %A Salls WB %A Schaeffer BA %A Pahlevan N %A Coffer MM %A Seegers BN %A Werdell PJ %A Ferriby H %A Stumpf RP %A Binding CE %A Keith DJ %J Remote Sens (Basel) %V 16 %N 11 %D 2024 May 30 %M 38994037 %F 5.349 %R 10.3390/rs16111977 %X Eutrophication of inland lakes poses various societal and ecological threats, making water quality monitoring crucial. Satellites provide a comprehensive and cost-effective supplement to traditional in situ sampling. The Sentinel-2 MultiSpectral Instrument (S2 MSI) offers unique spectral bands positioned to quantify chlorophyll a, a water-quality and trophic-state indicator, along with fine spatial resolution, enabling the monitoring of small waterbodies. In this study, two algorithms-the Maximum Chlorophyll Index (MCI) and the Normalized Difference Chlorophyll Index (NDCI)-were applied to S2 MSI data. They were calibrated and validated using in situ chlorophyll a measurements for 103 lakes across the contiguous U.S. Both algorithms were tested using top-of-atmosphere reflectances (ρ t), Rayleigh-corrected reflectances (ρ s), and remote sensing reflectances (R rs ). MCI slightly outperformed NDCI across all reflectance products. MCI using ρ t showed the best overall performance, with a mean absolute error factor of 2.08 and a mean bias factor of 1.15. Conversion of derived chlorophyll a to trophic state improved the potential for management applications, with 82% accuracy using a binary classification. We report algorithm-to-chlorophyll-a conversions that show potential for application across the U.S., demonstrating that S2 can serve as a monitoring tool for inland lakes across broad spatial scales.