%0 Journal Article
%T Organophosphate ester flame retardant chemicals and maternal depression during pregnancy.
%A Hernandez-Castro I
%A Eckel SP
%A Howe CG
%A Aung MT
%A Kannan K
%A Robinson M
%A Foley HB
%A Yang T
%A Vigil MJ
%A Chen X
%A Grubbs B
%A Al-Marayati L
%A Toledo-Corral CM
%A Habre R
%A Dunton GF
%A Farzan SF
%A Morales S
%A Breton CV
%A Bastain TM
%J Environ Res
%V 259
%N 0
%D 2024 Oct 15
%M 38992754
%F 8.431
%R 10.1016/j.envres.2024.119581
%X <B>BACKGROUND: </B>Depression substantially contributes to pregnancy-related morbidity, and pregnancy is increasingly recognized as a vulnerable window for exposure effects on maternal mental health. Exposures to organophosphate esters (OPEs) are ubiquitous and may have neurotoxic effects; however, their impacts on prenatal depression remain unknown. We evaluated associations of third trimester OPE metabolites on maternal depressive symptoms during pregnancy.<BR><B>METHODS: </B>This study included 422 participants in the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) cohort, a prospective pregnancy cohort of primarily low-income and Hispanic participants residing in Los Angeles, California. We measured concentrations of nine OPEs in third trimester spot urine samples (mean gestational age = 31.5 ± 2.0 weeks). Using the Center for Epidemiologic Studies-Depression (CES-D) scale, we classified participants as having probable depression during pregnancy (N = 137) or not (N = 285) if one or more CES-D scores administered at each trimester met the suggested cutoff score for clinically significant depressive symptoms (≥16). We estimated associations of prenatal OPE metabolite concentrations in tertiles and risk of prenatal depression using modified Log-Poisson regression. We examined associations of the OPE mixture on depression during pregnancy using Bayesian kernel machine regression (BKMR).<BR><B>RESULTS: </B>Participants with the highest tertiles of DPHP and BDCIPP exposure had a 67% (95% CI: 22%, 128%) and 47% (95% CI: 4%, 108%) increased risk of maternal depressive symptoms during pregnancy, respectively. No associations between other OPE metabolites and maternal depression symptoms were observed. In mixture analyses, we observed a positive and linear association between higher exposure to the OPE metabolite mixture and odds of prenatal maternal depression, primarily driven by DPHP.<BR><B>CONCLUSIONS: </B>Our findings provide new evidence of associations between frequently detected OPE metabolites on maternal depression symptoms during pregnancy. Results could inform future intervention efforts aimed at reducing perinatal maternal depression.