%0 Journal Article %T A crisis in clinical research. %A Hong DS %A LoRusso P %A Sznol M %J J Immunother Cancer %V 12 %N 7 %D 2024 Jul 11 %M 38991727 %F 12.469 %R 10.1136/jitc-2023-008520 %X The clinical research pipeline is critical to ensuring continued development of novel treatments that can offer patients with cancer safe and effective options. Unfortunately, progress has slowed since the COVID-19 pandemic due to uncovered, systemic inefficiencies across critical processes. Towards initiating discussion on how to reinvigorate clinical research, the Society for Immunotherapy of Cancer (SITC) hosted a virtual summit that characterized issues and formed potential solutions. This commentary serves to highlight the crisis facing clinical research as well as stimulate field-wide discussion on how to better serve patients into the future.