%0 Case Reports
%T Reevaluating Diagnosis of Sarcoidosis: Biopsy with Necrosis in Mycobacterial Endemic Areas.
%A Manwatkar AA
%A Das JK
%A Issac NPR
%A Kothapalli N
%A Chandhu AS
%A Prabhu V
%A Mathew J
%J J Assoc Physicians India
%V 72
%N 7
%D 2024 Jul
%M 38990593
暂无%R 10.59556/japi.72.0509
%X <B>BACKGROUND: </B>Sarcoidosis is a multisystem inflammatory disease with a variable presentation. The most characteristic feature of sarcoidosis is nonnecrotizing granulomas. However, when sarcoidosis presents with rare organ involvement, and biopsy shows necrosis, the diagnosis becomes challenging.<BR><B>METHODS: </B>Here, we present three cases of sarcoidosis with unusual organ involvement and biopsy findings of necrosis, leading to a delay in diagnosis and treatment. Case 1 was presented with lymphoreticular involvement within the intraparotid lymph node and genitourinary area. Biopsy from the epididymis showed necrosis, initially leading to treatment for tuberculosis (TB). Case 2 describes lymphoreticular involvement and cardiac symptoms. His cervical and bone marrow biopsies showed necrosis. Case 3's presentation was disseminated lymphadenopathy with hepatosplenomegaly, initially suspected as malignancy or TB.<BR><B>CONCLUSIONS: </B>While biopsy plays a significant role in diagnosing sarcoidosis, the presence of necrosis alone should not lead to its exclusion.