%0 Journal Article
%T Hormone replacement therapy and myocardial infarction and stroke in postmenopausal Korean women.
%A Baek JK
%A Kim HY
%A Kang MJ
%A Choi EA
%A Lee JK
%A Kim EH
%A Seo SK
%J Climacteric
%V 27
%N 4
%D 2024 Aug 19
%M 38990048
%F 3.024
%R 10.1080/13697137.2024.2354728
%X <B>UNASSIGNED: </B>This study aimed to investigate the association of hormone replacement therapy (HRT) use, type, duration and age of commencement with myocardial infarction (MI) and stroke in postmenopausal Korean women.<BR><B>UNASSIGNED: </B>This nested case-control study used data from the National Health Insurance Service database to analyze 2017 data from women aged ≥50 years and diagnosed with natural menopause between 2004 and 2007. Among 356,160 eligible women, 36,446 used HRT for ≥1 year and 319,714 did not (controls). These two groups were matched 1:1 for statistical analysis. Type and duration were categorized into three categories.<BR><B>UNASSIGNED: </B>Women who started estrogen-progestogen therapy (EPT) or estrogen therapy (ET) in their 50s, or EPT or tibolone in their ≥60s exhibited a lower stroke risk than controls. MI risk was lower among women who used tibolone - regardless of duration - or EPT or ET for 1-3 years than among controls. Stroke risk was lower with tibolone use for ≥5 years or with EPT or ET use for 1-3 years or ≥5 years than non-users.<BR><B>UNASSIGNED: </B>Our study may support the beneficial effect of HRT by showing that Korean postmenopausal women who used HRT at a relatively younger and healthier age had a relative benefit for MI and stroke.