%0 Journal Article %T Stress balls for the brain: How beading protects axons from mechanical damage. %A Leterrier C %J J Cell Biol %V 223 %N 8 %D 2024 Aug 5 %M 38985206 %F 8.077 %R 10.1083/jcb.202407024 %X The slender shape of axons makes them uniquely susceptible to mechanical stress. In this issue, Pan, Hu et al. (https://doi.org/10.1083/jcb.202206046) use a microfluidic axon-on-chip device to reveal how actomyosin protects axons from mild mechanical stress, by transiently adopting a beaded shape that helps limit the spread of damaging calcium waves.