%0 Journal Article
%T Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study.
%A Ulugut H
%A Bertoux M
%A Younes K
%A Montembeault M
%A Fumagalli GG
%A Samanci B
%A Illán-Gala I
%A Kuchcinski G
%A Leroy M
%A Thompson JC
%A Kobylecki C
%A Santillo AF
%A Englund E
%A Waldö ML
%A Riedl L
%A Van den Stock J
%A Vandenbulcke M
%A Vandenberghe R
%A Laforce R
%A Ducharme S
%A Pressman PS
%A Caramelli P
%A de Souza LC
%A Takada LT
%A Gurvit H
%A Hansson O
%A Diehl-Schmid J
%A Galimberti D
%A Pasquier F
%A Miller BL
%A Scheltens P
%A Ossenkoppele R
%A van der Flier WM
%A Barkhof F
%A Fox NC
%A Sturm VE
%A Miyagawa T
%A Whitwell JL
%A Boeve B
%A Rohrer JD
%A Gorno-Tempini ML
%A Josephs KA
%A Snowden J
%A Warren JD
%A Rankin KP
%A Pijnenburg YAL
%A  
%J Alzheimers Dement
%V 0
%N 0
%D 2024 Jul 10
%M 38982845
%F 16.655
%R 10.1002/alz.14076
%X <B>BACKGROUND: </B>Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype.<BR><B>METHODS: </B>Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments.<BR><B>RESULTS: </B>Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations.<BR><B>CONCLUSIONS: </B>This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients.<BR><B>CONCLUSIONS: </B>This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.