%0 Journal Article
%T Neurotoxic and behavioral deficit in Drosophila melanogaster exposed to photocatalytic products of Paraquat.
%A Ramalho DL
%A Silva JR
%A Brugnera MF
%A Moura S
%A de Oliveira Souza A
%J Neurotoxicology
%V 104
%N 0
%D 2024 Jul 7
%M 38981577
%F 4.398
%R 10.1016/j.neuro.2024.06.012
%X The Advanced Oxidative Processes have demonstrated potential for application in the degradation of organic pollutants, such as Paraquat (PQ) from water and wastewater, due to their low price, high efficiency, and non-toxic properties. In this study, we investigated whether the photodegradation of PQ with TiO2 nanotubes reduced its toxicity in Drosophila melanogaster. However, dietary ingestion of degradation products PQ for larvae resulted in a low axial ratio (pupal volume). In the adults, products of photodegradation of PQ exposure markedly diminished climbing ability in a time-dependent manner after 10 days of feeding. In addition, exposure of D. melanogaster to photodegradation of PQ reduced acetylcholinesterase and citrate synthase activities but improved oxidative stress, as evidenced by oxide nitric, protein carbonyl, and lactate production. These results suggest that the photodegradation of PQ with TiO2 nanotubes produced PQ fragments with higher toxicity than PQ, while the precise mechanism of its action needs further investigation.