%0 Journal Article
%T Mixed Shock Complicating Cardiogenic Shock: Frequency, Predictors, and Clinical Outcomes.
%A Baldetti L
%A Gallone G
%A Filiberti G
%A Pescarmona L
%A Cesari A
%A Rizza V
%A Roagna E
%A Gurrieri D
%A Peveri B
%A Nocera L
%A Cianfanelli L
%A Marcelli G
%A De Lio G
%A Boretto P
%A Angelini F
%A Gramegna M
%A Pazzanese V
%A Sacchi S
%A Calvo F
%A Ajello S
%A De Ferrari GM
%A Frea S
%A Scandroglio AM
%J Circ Heart Fail
%V 17
%N 7
%D 2024 Jul 9
%M 38979611
%F 10.447
%R 10.1161/CIRCHEARTFAILURE.123.011404
%X UNASSIGNED: Patients presenting with cardiogenic shock (CS) are at risk of developing mixed shock (MS), characterized by distributive-inflammatory phenotype. However, no objective definition exists for this clinical entity.
UNASSIGNED: We assessed the frequency, predictors, and prognostic relevance of MS complicating CS, based on a newly proposed objective definition. MS complicating CS was defined as an objective shock state secondary to both an ongoing cardiogenic cause and a distributive-inflammatory phenotype arising at least 12 hours after the initial CS diagnosis, as substantiated by predefined longitudinal changes in hemodynamics, clinical, and laboratory parameters.
UNASSIGNED: Among 213 consecutive patients admitted at 2 cardiac intensive care units with CS, 13 with inflammatory-distributive features at initial presentation were excluded, leading to a cohort of 200 patients hospitalized with pure CS (67±13 years, 96% Society of Cardiovascular Angiography and Interventions CS stage class C or higher). MS complicating CS occurred in 24.5% after 120 (29-216) hours from CS diagnosis. Lower systolic arterial pressure (P=0.043), hepatic injury (P=0.049), and suspected/definite infection (P=0.013) at CS diagnosis were independent predictors of MS development. In-hospital mortality (53.1% versus 27.8%; P=0.002) and hospital stay (21 [13-48] versus 17 [9-27] days; P=0.018) were higher in the MS cohort. At logistic multivariable analysis, MS diagnosis (odds ratio [OR], 3.00 [95% CI, 1.39-6.63]; Padj=0.006), age (OR, 1.06 [95% CI, 1.03-1.10] years; Padj<0.001), admission systolic arterial pressure <100 mm Hg (OR, 2.41 [95% CI, 1.19-4.98]; Padj=0.016), and admission serum creatinine (OR, 1.61 [95% CI, 1.19-2.26]; Padj=0.003) conferred higher odds of in-hospital death, while early temporary mechanical circulatory support was associated with lower in-hospital death (OR, 0.36 [95% CI, 0.17-0.75]; Padj=0.008).
UNASSIGNED: MS complicating CS, objectively defined leveraging on longitudinal changes in distributive and inflammatory features, occurs in one-fourth of patients with CS, is predicted by markers of CS severity and inflammation at CS diagnosis, and portends higher hospital mortality.