%0 Journal Article
%T GATA2 deficiency syndrome: A compensatory mechanism gone awry?
%A Rio-Machin A
%J Br J Haematol
%V 205
%N 2
%D 2024 Aug 8
%M 38977272
%F 8.615
%R 10.1111/bjh.19638
%X In their paper, using zebrafish models, Gioacchino et al. have demonstrated the GATA2 haploinsufficiency, the genetic hallmark of GATA2 deficiency syndrome, promotes erythroid and myeloid cytopenia, and have discovered a self-regulatory mechanism to compensate GATA2 levels and protein function. Commentary on: Gioacchino et al. GATA2 heterozygosity causes an epigenetic feedback mechanism resulting in myeloid and erythroid dysplasia. Br J Haematol 2024;205:580-593.