%0 Journal Article
%T Identifying a Level of Neutralizing Antibody That Correlates With Protection From Clinical Mumps Disease During a 2017 Mumps Outbreak Among Military Service Members.
%A Sowers SB
%A Clemmons NS
%A Mercader S
%A Nielsen L
%A Colley H
%A Jordan NN
%A Bettger CC
%A Masters NB
%A Markelz AE
%A Hickman CJ
%J Open Forum Infect Dis
%V 11
%N 7
%D 2024 Jul
%M 38975246
%F 4.423
%R 10.1093/ofid/ofae329
%X <B>UNASSIGNED: </B>In 2017, a mumps outbreak occurred in a US military barracks. Serum collected at service entry was used to compare pre-exposure with presumptive vaccine-induced antibody levels from persons who developed mumps (cases) and potentially exposed persons who did not develop mumps (non-cases). Sufficient information to determine levels of exposure during the outbreak was not available.<BR><B>UNASSIGNED: </B>Pre-outbreak serum samples from the Department of Defense Serum Repository were available from 254 potentially exposed service members. Twelve developed clinical symptoms and had post-outbreak serum collected. All sera were tested with a mumps-specific enzyme immunoassay for immunoglobulin M, immunoglobulin G (IgG), and IgG avidity. The neutralizing antibodies to vaccine strain (Jeryl Lynn [JL], genotype A) and wildtype virus (genotype G) was assessed by a plaque reduction neutralization test. A Fisher exact test and receiver operator characteristic curve were used to analyze the antibody response for non-cases and mumps cases.<BR><B>UNASSIGNED: </B>Eight mumps cases were laboratory confirmed. Pre-outbreak neutralizing antibody titers to JL and genotype G mumps virus and pre-outbreak IgG index values were proportionately lower for most cases as compared with exposed non-cases. When compared with potentially exposed non-cases, cases with clinical symptoms had greater odds of having a pre-outbreak JL titer <41 and a genotype G titer <16.<BR><B>UNASSIGNED: </B>We identified potential correlates of protection for mumps neutralizing antibody titers against JL and genotype G mumps viruses.