%0 Case Reports
%T "Intraosseous administration of tenecteplase for thrombolysis of an acute ischemic stroke".
%A Chung J
%A Bundy J
%A Khan S
%A Hunt A
%A Carroll S
%A Ali A
%A Shafi N
%A Tesoro E
%J J Stroke Cerebrovasc Dis
%V 33
%N 9
%D 2024 Sep 4
%M 38971481
%F 2.677
%R 10.1016/j.jstrokecerebrovasdis.2024.107850
%X <B>BACKGROUND: </B>Current guidelines for acute ischemic stroke recommend timely administration of intravascular thrombolytic therapy to promote functional and neurologic outcomes. Tenecteplase is an emerging off-label therapy for this indication and being utilized by various institutions due to its simpler administration strategy. In emergent situations in which intravenous access cannot be obtained, intraosseous access is a viable option for medication administration. However, there has been minimal published cases to support the efficacy and safety of intraosseous administration of tenecteplase for acute ischemic stroke.<BR><B>METHODS: </B>We describe the case of a 51-year-old woman who developed acute ischemic stroke within our institution. Due to difficulty achieving intravenous access and time-dependent efficacy of thrombolytic therapy, the decision was made to administer tenecteplase by the intraosseous route. Stroke symptoms improved within 48 hours following administration without complication.<BR><B>CONCLUSIONS: </B>Intraosseous administration of tenecteplase may be considered for treatment of acute ischemic stroke if intravenous access is unattainable.