%0 Journal Article
%T Echocardiography Core Laboratory Methodology for TAVR: A Transatlantic Consensus.
%A Ren CB
%A Tardif D
%A Brandenburg HJ
%A Roux M
%A Mrevlje B
%A Geleijnse ML
%A Van Mieghem NM
%A Spitzer E
%A Pibarot P
%J JACC Cardiovasc Imaging
%V 0
%N 0
%D 2024 Jun 20
%M 38970592
%F 16.051
%R 10.1016/j.jcmg.2024.04.014
%X Inter-echocardiography core laboratory (ECL) harmonization is pivotal to consider data from different ECLs interchangeable. On the basis of the experience of the first trans-Atlantic harmonization of 2 established ECLs in the field of transcatheter aortic valve replacement (TAVR) trials, this review describes the harmonized ECL methodology in analyzing and adjudicating the post-TAVR echocardiographic endpoints according to Valve Academic Research Consortium 3 definitions. This review presents the feasibility and intra- and inter-ECL reproducibility, explains the root cause of potential important inter-ECL variability, and formulates ECL recommendations for optimal post-TAVR echocardiographic image acquisition. The implementation of inter-ECL harmonization may further define the best practice of ECLs and have logistic and regulatory implications for the realization of future TAVR trials.