%0 Journal Article
%T Relationships of Office, Ambulatory, and Self-Measured Blood Pressure with Cardiac, Renal, and Atherosclerotic Biomarkers.
%A Narita K
%A Hoshide S
%A Kario K
%J Am J Hypertens
%V 0
%N 0
%D 2024 Jul 5
%M 38970332
%F 3.08
%R 10.1093/ajh/hpae083
%X <B>BACKGROUND: </B>Previous studies with several limitations have comparatively analyzed the relationship between ambulatory blood pressure (BP) and self-measured BP and biomarkers of organ damage. This study extends this line of research by examining the relationship between ambulatory and self-measured BP and cardiac, renal, and atherosclerotic biomarkers in outpatients at cardiovascular risk.<BR><B>METHODS: </B>In 1,440 practice outpatients who underwent office, ambulatory, and self-measured BP monitoring, we assessed the relationships of each BP with organ damage biomarkers including b-type natriuretic peptide (BNP), echocardiographic left ventricular mass index (LVMI), urine-albumin-creatinine ratio (UACR), and brachial-ankle pulse wave velocity (baPWV).<BR><B>RESULTS: </B>In the comparison of correlation, self-measured systolic BP (SBP) was more strongly correlated to log-transformed (Ln) BNP (n=1,435; r=0.123 vs. r = -0.093, P<0.001), LVMI (n=1,278; r=0.223 vs. r=0.094, P<0.001), Ln-UACR (n=1,435; r=0.244 vs. r=0.154, P=0.010), and baPWV (n=1,360; r=0.327 vs. r=0.115, P<0.001) than daytime ambulatory SBP. In the linear regression models including office, ambulatory, and self-measured SBP, only self-measured SBP was significantly related to Ln-BNP (P=0.016) and LVMI (P<0.001). In the logistic regression models for the top quartile of LVMI, adding self-measured SBP improved the model predictability (P=0.027), but adding daytime ambulatory SBP did not. However, adding daytime ambulatory SBP improved the model predictability in the logistic model including office and self-measured SBP.<BR><B>CONCLUSIONS: </B>Our study findings suggested that self-measured BP was associated with cardiac biomarkers independent of ambulatory BP.