%0 Journal Article
%T Improved brain effective connectivity modeling by dynamic Bayesian networks.
%A Ulusoy I
%A Geduk S
%J J Neurosci Methods
%V 0
%N 0
%D 2024 Jul 3
%M 38968975
%F 2.987
%R 10.1016/j.jneumeth.2024.110211
%X <B>BACKGROUND: </B>If brain effective connectivity network modelling (ECN) could be accurately achieved, early diagnosis of neurodegenerative diseases would be possible. It has been observed in the literature that Dynamic Bayesian Network (DBN) based methods are more successful than others. However, DBNs have not been applied easily and tested much due to computational complexity problems in structure learning.<BR><B>METHODS: </B>This study introduces an advanced method for modelling brain ECNs using improved discrete DBN (Improved- dDBN) which addresses the computational challenges previously limiting DBN application, offering solutions that enable accurate and fast structure modeling.<BR><B>RESULTS: </B>The practical data and prior sizes needed for the convergence to the globally correct network structure are proved to be much smaller than the theoretical ones using simulated dDBN data. Besides, Hill Climbing is shown to converge to the true structure at a reasonable iteration step size when the appropriate data and prior sizes are used. Finally, importance of data quantization methods are analysed.<BR><B>METHODS: </B>The Improved-dDBN method performs better and robust, when compared to the existing methods for realistic scenarios such as varying graph complexity, various input conditions, noise cases and non-stationary connections. The data used in these tests is the simulated fMRI BOLD time series proposed in the literature.<BR><B>CONCLUSIONS: </B>Improved-dDBN is a good candidate to be used on real datasets to accelerate developments in brain ECN modeling and neuroscience. Appropriate data and prior sizes can be identified based on the approach proposed in this study for global and fast convergence.