%0 Journal Article
%T The impact of preservation solutions for static cold storage on kidney transplantation outcomes: Results of a Brazilian nationwide multicenter study.
%A Sandes-Freitas TV
%A Moura LR
%A Carvalho DRBM
%A Garcia VD
%A Modelli de Andrade LG
%A Mazzali M
%A Manfro RC
%A Deboni LM
%A Davi-Neto E
%A Oliveira CMC
%A Cavalcanti FCB
%A Madeira RL
%A Esmeraldo RM
%A Simão DR
%A Meira ACG
%A Ferreira GF
%A Lasmar M
%A Bignelli AT
%A Pacheco-Silva A
%A Medina Pestana J
%A Tedesco Silva H
%A  
%J PLoS One
%V 19
%N 7
%D 2024
%M 38968266
%F 3.752
%R 10.1371/journal.pone.0306056
%X This study evaluated the current practices of selecting cold storage preservation solutions in Brazil and their impact on delayed graft function (DGF) incidence and 1-year outcomes in kidney transplant recipients. A retrospective cohort study was conducted, including 3,134 brain-dead deceased donor kidney transplants performed between 2014 and 2015 in 18 Brazilian centers. The most commonly used preservation solution was Euro-collins (EC, 55.4%), followed by Histidine-tryptophan-ketoglutarate (HTK, 30%) and Institut Georges Lopez (IGL-1, 14.6%). The incidence of DGF was 54.4%, with 11.7% of patients requiring dialysis for more than 14 days, indicating prolonged DGF. Upon adjusting for confounding variables, HTK demonstrated a significantly lower risk of DGF than EC (OR 0.7350.82500.926), as did IGL-1 (OR 0.6050.7120.837). Similar protective effects were observed for prolonged DGF when comparing HTK (OR 0.4780.5990.749) and IGL-1 (OR 0.4780.6810.749) against EC. No significant association was found between preservation solutions and 1-year death-censored graft survival. In conclusion, EC was the most frequently used cold storage perfusion solution, demonstrating a higher incidence and duration of DGF compared with HTK and IGL-1, but with no impact on 1-year graft survival.