%0 Journal Article
%T [Progress of allogeneic hematopoietic stem cell transplantation in KMT2A-rearranged acute leukemia].
%A Liu J
%A Huang XJ
%J Zhonghua Xue Ye Xue Za Zhi
%V 45
%N 5
%D 2024 May 14
%M 38964931
暂无%R 10.3760/cma.j.cn121090-20231026-00230
%X KMT2A (lysine methyltransferase 2A) -rearranged acute leukemia is a class of leukemia with unique biological characteristics with moderate or poor prognosis. In recent years, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been increasingly indicated for patients with KMT2A-rearranged acute leukemia. By reviewing the clinical studies of allo-HSCT in KMT2A-rearranged acute leukemia, the efficacy of allo-HSCT in children and adults with KMT2A-rearranged acute myeloid leukemia and acute lymphoblastic leukemia was assessed, the factors affecting the prognosis of allo-HSCT were summarized, and the methods that may improve the outcomes of allo-HSCT were explored.<BR>KMT2A重排急性白血病是具有独特生物学特性的一类白血病，其预后中等或不良。近年来，异基因造血干细胞移植（allo-HSCT）在KMT2A重排急性白血病中的应用日趋广泛。本文通过综述allo-HSCT治疗KMT2A重排急性白血病临床研究进展，分析allo-HSCT在儿童及成人KMT2A重排急性髓系白血病和急性淋巴细胞白血病中的疗效，归纳影响allo-HSCT预后的因素，并探讨可能改善allo-HSCT预后的方法。.