%0 English Abstract
%T [Correlation analysis of polyclonal plasma cell proportion in the bone marrow with clinical characteristics of patients with newly diagnosed multiple myeloma].
%A Long XL
%A Wang XR
%A An N
%A Liu SY
%A Li Z
%A Li CH
%A Mu W
%A Wang D
%A Li CR
%J Zhonghua Xue Ye Xue Za Zhi
%V 45
%N 5
%D 2024 May 14
%M 38964922
暂无%R 10.3760/cma.j.cn121090-20231020-00221
%X Objective: To explore the correlation of bone marrow polychonal plasma cell proportion (pPC% ) and clinical features in newly diagnosed multiple myeloma (NDMM) patients. Methods: A retrospective analysis of 317 patients with NDMM admitted to Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2018 to January 2023 was performed. The results of the pPC% in all patients were clear. The relationship between the pPC% and clinical characteristics was analyzed. Results: A total of 317 patients were included, comprising 180 males and 137 females. The median age at diagnosis was 61 (26-91) years, and 55.8% were 60 years or older. The pPC% in the bone marrow of patients with NDMM was different in the DS, International Staging System (ISS), and revised ISS (R-ISS) stages (P=0.002, 0.010, and 0.049, respectively), whereas no statistical difference in pPC% was observed among patients with different FISH risk stratigrams (P=0.971). The correlation coefficient between pPC% and hemoglobin (HGB) at the first diagnosis in patients was 0.211 (P<0.01). The correlation coefficients with serum calcium, serum creatinine, M protein level, and β(2)-microglobulin were -0.141, -0.120, -0.181, and -0.207, respectively, and the results of the significance test were P=0.012, 0.033, 0.004, and 0.002, respectively, indicating a negative correlation. Compared with the patients with a pPC% of ≥2.5%, the group of patients with a pPC% of <2.5% had significantly higher levels of light chain, serum calcium, serum creatinine, M protein, and β(2)-microglobulin at the initial diagnosis (P<0.05) ; lower HGB level (P<0.001) ; and a higher proportion of patients in ISS stage Ⅲ (P=0.034) . Conclusion: In this study, the pPC% in patients with NDMM was associated with clinical features of good prognosis, including higher HGB, lower serum calcium, serum creatinine, M protein quantity, β(2)-microglobulin, light chain involvement, lower proportion of advanced disease (DS stage and ISS stage Ⅲ), and clinical features showing lower tumor burden.<BR>目的： 探究初诊多发性骨髓瘤（NDMM）患者骨髓多克隆浆细胞占比（pPC%）与临床特征的相关性。 方法： 回顾性分析2018年1月至2023年1月在华中科技大学同济医学院附属同济医院收治的317例NDMM患者，纳入患者均有明确的pPC%结果。分析pPC%与临床特征的关系。 结果： 共纳入317例患者，其中男180例，女137例，中位确诊年龄61（26～91）岁，≥60岁患者占55.8%。NDMM患者骨髓pPC%在各DS分期、ISS分期、R-ISS分期组差异均有统计学意义（P值分别为0.002、0.010、0.049），而不同的FISH危险分层患者pPC%差异无统计学意义（P＝0.971）。NDMM患者pPC%与患者初诊时HGB呈正相关（r＝0.211，P<0.01）；与血钙、血肌酐、单克隆免疫球蛋白（M蛋白）定量、β(2)微球蛋白水平呈负相关（r分别为-0.141、-0.120、-0.181、-0.207，P值为0.012、0.033、0.004、0.002）。与pPC%≥2.5%患者相比，pPC%<2.5%组患者初诊时受累轻链、血钙、血肌酐、M蛋白和β(2)微球蛋白水平明显升高（P值均<0.05），HGB降低（P<0.001），ISS分期Ⅲ期比例更高（P＝0.034）。 结论： NDMM患者pPC%与良好预后的临床特征相关，包括更高的HGB，更低的血钙、血肌酐、M蛋白定量、β(2)微球蛋白，受累轻链，更低的晚期疾病占比（DS分期、ISS分期Ⅲ期），在临床特点上表现为肿瘤负荷较小。.